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In vitro 3D human small intestinal villous model for drug permeability determination

โœ Scribed by Jiajie Yu; Songming Peng; Dan Luo; John C. March


Book ID
112012871
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
523 KB
Volume
109
Category
Article
ISSN
0006-3592

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The aim of this study was to ยฎnd a cell culture model of the intestinal epithelium for use in studies of CYP3A4-mediated ยฎrst-pass metabolism of drugs and also for studies of the interplay between CYP3A4 metabolism and P-glycoprotein efยฏux. For this purpose, the expression of CYP3A4, CYP3A5, and MDR