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In the absence of AIRE...

โœ Scribed by Leavy, Olive


Book ID
109955499
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
132 KB
Volume
6
Category
Article
ISSN
1474-1741

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Diversity and clonotypic composition of
โœ Katherine Kedzierska; Sophie A. Valkenburg; Carole Guillonneau; Francois-Xavier ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 381 KB ๐Ÿ‘ 2 views

TCR repertoire diversity is important for the protective efficacy of CD8 1 T cells, limiting viral escape and cross-reactivity between unrelated epitopes. The exact mechanism for selection of restricted versus diverse TCR repertoires is far from clear, although one thought is that the epitopes resem