Diversity and clonotypic composition of
โ
Katherine Kedzierska; Sophie A. Valkenburg; Carole Guillonneau; Francois-Xavier
๐
Article
๐
2010
๐
John Wiley and Sons
๐
English
โ 381 KB
๐ 2 views
TCR repertoire diversity is important for the protective efficacy of CD8 1 T cells, limiting viral escape and cross-reactivity between unrelated epitopes. The exact mechanism for selection of restricted versus diverse TCR repertoires is far from clear, although one thought is that the epitopes resem