Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of the intrahepatic bile ducts. It is generally believed that cellular immune mechanisms, particularly involving T cells, result in this bile duct damage. The relative strength of Th1 and Th2 responses has re
In situ nucleic acid hybridization
โ Scribed by William R. Freeman; Clayton A. Wiley
- Book ID
- 116068924
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 704 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0039-6257
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Pyruvate dehydrogenase-E2, or a cross-reactive molecule, has been shown by a variety of immunohistochemical methods to be present in increased amounts in biliary epithelial cells (BEC) in primary biliary cirrhosis (PBC). In this study, to further understand the nature of the immunoreactive molecule
It is possible to combine hybridization to specimens on electron-microscope grids of nucleic-acid probes labelled nonisotopically with immunogold detection of hybrid sites to map the position of target sequences rapidly and precisely. The basic technique is described, and examples are provided to il