## Abstract Pharmaceutical solids exposed to thermal stress during manufacturing processes undergo various phase transformations in bulk drug substances or excipients, resulting in altered dosage form performance. Due to its relatively rapid spectral acquisition rate, as well as the possibility of
✦ LIBER ✦
In situ monitoring of solid-state transition of p-aminobenzoic acid polymorphs using Raman spectroscopy
✍ Scribed by Xia Yang; Xiujuan Wang; Chi Bun Ching
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 371 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0377-0486
- DOI
- 10.1002/jrs.2185
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## Abstract The aim of this work was to investigate the mechanism and progression of the solution‐mediated polymorphic transformation and crystallization of glycine. The identification of the α‐ and γ‐forms of glycine crystals was performed using powder X‐ray diffraction (PXRD), Raman microscopy an