In Situ Micro-Sized Gel-Forming Injectable Implant Using Biodegradable Amphiphilic Graft Copolymer
✍ Scribed by Kuk Young Cho; Seongnam Lee; Jung-Ki Park
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 193 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
A synthesized graft polymer is used as a biodegradable polymer for an in situ gel‐forming injectable implant system. The amphiphilic character of the polymer in the graft structure lowered the viscosity of the polymer solution, which enabled easy injection. A micro‐sized gel can be obtained with this system, which has not been found for previous in situ gel‐forming systems with poly[(D,L‐lactide)‐co‐glycolide] copolymer. In addition, a protein particle embedded gel exhibits good in vitro drug release performance as a result of the enhanced stability and shorter diffusion length.
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