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In situ hybridization study of growth hormone, prolactin, and proopiomelanocortin mRNAs in adenohypophyses of mice transgenic for human growth hormone

✍ Scribed by L. Stefaneanu; K. Kovacs; A. Bartke

Book ID
112935836
Publisher
Springer US
Year
1993
Tongue
English
Weight
865 KB
Volume
4
Category
Article
ISSN
1046-3976

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To develop transgenic mice, a mouse metallothionein promoter-human growth hormone (Mt-hGH) gene fragment was injected into the pronucleus of C57BI X DBN2J F, onecell embryos. Six founder animals grew larger (I 3-2.2 times) than littermate controls and had higher levels of hGH in plasma (4.6279 mUII)