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In situ hybridization studies of α2-macroglobulin receptor and receptor-associated protein in human prostate carcinoma

✍ Scribed by McGarvey, T.; Hussain, M. M.; Stearns, M. E.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
593 KB
Volume
28
Category
Article
ISSN
0270-4137

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✦ Synopsis

We have utilized in situ hybridization and immunocytochemistry techniques to examine the expression of both a,-macroglobulin (a,-MR) and the 39 kDa receptorassociated protein (RAP) in 8 benign (BPH) and 34 malignant human prostate tissues, including 4 metastases. The levels of a,-MR mRNA expression (but not RAP) increased sigruhcantly in high Gleason score carcinomas (3) and in metastatic lesions, suggesting that a,-MR expression is associated with advanced cancer. Semi-quantitative analysis with computer-assisted system analysis (CASA) confirmed this interpretation. This is the first report of a,-MR expression being associated with advanced prostate cancer.

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