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In Situ Forming Poly(ethylene glycol)- Poly(L-lactide) Hydrogels via Michael Addition: Mechanical Properties, Degradation, and Protein Release

✍ Scribed by Sytze J. Buwalda; Pieter J. Dijkstra; Jan Feijen

Book ID: 112141280
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 573 KB
Volume: 213
Category: Article
ISSN: 1022-1352
DOI: 10.1002/macp.201100640

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## Abstract An acryloyl end-capped four-arm star-shaped poly(ethylene glycol)-branched-oligo(l-lactide) (4A-PEG-PLA) macromer was firstly prepared. A novel kind of hydrogels was synthesized via the Michael-type addition reaction between (2S,3S)-1,4-bis-sulfanylbutane-2,3-diol (dithiothreitol) and t