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In Situ Forming Physical Hydrogels for Three-dimensional Tissue Morphogenesis

✍ Scribed by Yang Liu; Bo Liu; Jeremiah J. Riesberg; Wei Shen

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 509 KB
Volume: 11
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201100119

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✦ Synopsis

Abstract

In situ forming physical hydrogels are formed through a biologically benign reaction between two multi‐arm macromers, one containing terminal thiol and the other containing terminal vinyl sulfone groups. One macromer is self‐assembled through a coiled‐coil domain; and the physical junction of this macromer confers the physical nature to the whole network. Unlike covalently cross‐linked hydrogels in which material degradation is a prerequisite for three‐dimensional cell movement, these physical hydrogels have junctions that undergo reversible dissociation and re‐association, constitutively opening paths for cell movement. Epithelial cells encapsulated in these hydrogels can form hollow spherical cysts without the need for material degradation.

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