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In situ expression of the CTLA-4 receptor in T-cell-mediated inflammatory and neoplastic skin diseases

✍ Scribed by M. Alaibac; A. Belloni Fortina; A. Poletti; P. Vandenberghe; F. Marino; M. Tarantello; A. Peserico

Book ID
106079171
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
112 KB
Volume
292
Category
Article
ISSN
0340-3696

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The CTLA4 receptor is a CD28 homologue which induces inhibitory effect on activated T-cells. Peripheral T-cells proliferate spontaneously in CTLA4-deficient mice. These results led to an analysis of CTLA4 expression in human lymphomas (n=82) including Hodgkin's disease (HD) and non-Hodgkin's lymphom