In situ detection of insulin-like growth factor II (IGF2) andH19gene expression in hepatocellular carcinoma
โ Scribed by T. Sohda; Kaoru Iwata; Hidenobu Soejima; Seiichiro Kamimura; Hiroshi Shijo; Kankatsu Yun
- Book ID
- 106252413
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 407 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1435-232X
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In this study we investigated the regulation of insulin-like growth factor II gene expression to explain a role for this growth factor in concert with hepatitis B virus involvement in the development of hepatocellular carcinoma from cirrhosis. Sections of normal liver and tumor and non-tumor-bearing
The insulin-like growth factor 2 (IGF2) gene is regulated in a complex manner, involving developmentally regulated use of four different promoters as well as transcriptional repression of the maternal allele due to genomic imprinting. It has been well documented that liver is an exceptional organ in
We investigated expression of insulin-like growth factor II (Igf2) in primary cultured hepatocytes, liver epithelial (LE) cell lines derived from normal hepatocytes, and hepatocellular carcinoma (HCC) cell lines from crosses between C3H/HeJ (C3H) and Mus musculus molossinus mice (MSM). Igf2 mRNA was