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In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons

✍ Scribed by Taro Saito; Koichi Ishiguro; Tsuneko Uchida; Eishichi Miyamoto; Takeo Kishimoto; Shin-ichi Hisanaga

Book ID
115931619
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
524 KB
Volume
376
Category
Article
ISSN
0014-5793

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Protein phosphatase inhibitors induce modification of synapse structure and tau hyperphosphorylation in cultured rat hippocampal neurons
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## Protein phosphatase inhibitors, okadaic acid and Caliculin A, were used to investigate how perturbation of phosphorylation and dephosphorylation processes might affect neurite and synapse structure in cultures of fetal rat hippocampal neurons. Drug treatments induced neuritic tree modification,