In silico analysis for transcription factors with Zn(II)2C6 binuclear cluster DNA-binding domains in Candida albicans
✍ Scribed by Sergi Maicas; Inmaculada Moreno; Almudena Nieto; Micaela Gómez; Rafael Sentandreu; Eulogio Valentín
- Publisher
- Hindawi Publishing Corporation
- Year
- 2005
- Tongue
- English
- Weight
- 342 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1531-6912
- DOI
- 10.1002/cfg.492
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✦ Synopsis
A total of 6047 open reading frames in the__Candida albicans__genome were screened forZn(II)2C6-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of theCysX2CysX6CysX5-16CysX2CysX6-8Cysmotif and a putative nuclear localization signal. Using this approach, 70 putativeZn(II)2C6transcription factors have been found in the genome of__C. albicans__.