In search of the psychosis gene in people with Prader-Willi syndrome
β Scribed by Tessa Webb; Esther N. Maina; Sarita Soni; Joyce Whittington; Harm Boer; David Clarke; Anthony Holland
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 222 KB
- Volume
- 146A
- Category
- Article
- ISSN
- 1552-4825
No coin nor oath required. For personal study only.
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## Abstract PraderβWilli syndrome (PWS) is caused by loss of function of paternally expressed genes in the 15q11βq13 region and a paucity of data exists on transcriptome variation. To further characterize genetic alterations in this classic obesity syndrome using whole genome microarrays to analyze
The Prader-Willi syndrome (PWS) usually results from a paternal deletion of 15q11-q13 or maternal disomy for chromosome 15. Reduced pigmentation of skin, hair, and eyes is common in PWS and was suggested previously to be associated with the 15q11-q13 deletion. The P gene, located in this same region