𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In search of the ‘bio-active conformation’—Is it induced by the target cell membrane?

✍ Scribed by Robert Schwyzer

Book ID
102903690
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
648 KB
Volume
8
Category
Article
ISSN
0952-3499

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✦ Synopsis

Abstract

Conformations of regulatory peptides interacting lipid membranes were compared with those of chemically constrained molecules that react‐selectively with different receptor classes. Striking similarities in the topochemistry of molecules with similar activity were observed, The membrane‐induced topomers were almost congruent with the topomers that are selectively recognized by the same receptors. Finally, the ideas developed in the membrane compartments theory allow a quantitative prediction of receptor preference are compatible with our present knowledge of receptor structure.

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A conformational change in the lactose p
A conformational change in the lactose permease of Escherichia coli is induced by ligand binding or membrane potential
✍ Heinrich Jung; Kirsten Jung; H. Ronald Kaback 📂 Article 📅 1994 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 607 KB

## Abstract Lactose transport in membrane vesicles containing lactose permease with a single Cys residue in place of Val 315 is inactivated by __N__‐ethylmaleimide in a manner that is stimulated by substrate or by a H^+^ electrochemical gradient (δμ, Sahin‐Tóth M, Kaback HR, 1993, __Protein Sci 2__