Octanolβwater partition of nonzwitterion
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Peter Buchwald; Nicholas Bodor
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Article
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1998
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John Wiley and Sons
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English
β 146 KB
π 2 views
A remarkably simple, molecular size-based model developed to predict octanol-water partition coefficients for organic compounds is tested on a set of 188 neutral peptides with available experimental partition data. Despite using only two parameters, it gives a promising correlation (r 2 β«Ψβ¬ 0.914; β«