Impurities in drugs II: Meperidine and its formulations

✍ Scribed by K. M. McErlane; R. J. Wood; F. Matsui; E. G. Lovering

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 468 KB
• Volume: 67
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600670723

✦ Synopsis

Three lots of meperidine hydrochloride, seven lots of meperidine tablets, and 41 lots of meperidine injectables were examined for impurities by TLC. Impurities found were ethyl 1-benzyl-4-phenyl-4-piperidinecarboxylate, methyl-4-piperidinecarboxylate, ethyl-4-phenyl-4-piperidinecarboxylate, and three unidentified compounds. Not all impurities were found in every lot of drug investigated, and none of the impurities exceeded a concentration of 1% of the meperidine present.