Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy
✍ Scribed by Sean S. O'Sullivan; Atbin Djamshidian; Zeshan Ahmed; Andrew H. Evans; Andrew D. Lawrence; Janice L. Holton; Tamas Revesz; Andrew J. Lees
- Book ID
- 102945465
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 587 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
There is growing awareness of impulsive‐compulsive spectrum behaviors (ICBs) in patients with Parkinson's disease (PD) treated with dopamine replacement therapy (DRT). These include pathological gambling, hypersexuality, compulsive shopping, binge eating, punding and compulsive use of DRT, or dopamine dysregulation syndrome. In PD, difficulties exist in separating the effects of DRT from the underlying disease process and aberrant dopaminergic systems in determining the aetiology of ICBs. Recent reports of ICBs associated with dopamine agonist use for conditions other than PD may suggest a significant etiological role for these medications, but currently published cases thus far lack pathological confirmation of diagnoses. We present three cases of pathologically confirmed progressive supranuclear palsy who developed ICBs in association with dopamine agonist use. Pathological comparisons between these three cases and other case series of progressive supranuclear palsy are made. © 2010 Movement Disorder Society