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Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

โœ Scribed by Tobias Wunberg; Martin Hendrix; Alexander Hillisch; Mario Lobell; Heinrich Meier; Carsten Schmeck; Hanno Wild; Berthold Hinzen


Book ID
114385294
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
254 KB
Volume
11
Category
Article
ISSN
1359-6446

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The enormous cost incurred when a candidate drug fails in a clinical trial because of poor pharmacological parameters or severe side effects makes it imperative to screen for "safe" drugs in the very early stages of drug development. Various biochemical and other in vitro assays are thus used in con