Improving the efficiency of the formalin test
β Scribed by Frances V. Abbott; Rok Ocvirk; Robert Najafee; Keith B.J. Franklin
- Book ID
- 117480404
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 679 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0304-3959
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The subcutaneous injection of formalin into the rat upper lip generates behavioral responses that last several minutes. The time course of the response is similar to what is observed following formalin injection into the paw, i.e. biphasic, with an early and short-lasting first phase followed, after
The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection.