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Improving Pharmacokinetic–Pharmacodynamic Models of Muscle Relaxants Using Potentiation Modelling

✍ Scribed by Douglas J. Eleveld; Johannes H. Proost; Ann Haes; J. Mark K. H. Wierda

Publisher
Springer
Year
2005
Tongue
English
Weight
270 KB
Volume
32
Category
Article
ISSN
1573-8744

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✍ V. Nigrovic; J. Gaspari; M. Banoub 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 832 KB

Our goal was to develop a pharmacokinetic-pharmacodynamic model that describes the fate of atracurium and its metabolite laudanosine as well as the time course of the neuromuscular block. The model was based on the consideration of mass balance of atracurium and was constructed by postulating an eff