Improved intestinal transport of PD 1584
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Doo-Man Oh; Hyo-Kyung Han; Rufus M. Williamson; Christopher F. Bigge; Gordon L.
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Article
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2002
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John Wiley and Sons
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English
⚖ 137 KB
The objective of this research was to determine the characteristics of intestinal transport of PD 0158473 using in vitro Caco-2 cells as well as in situ single-pass rat intestinal perfusion models. Because apical (AP)-to-basolateral (BL) transport was greater (1.8- fold) than BL-to-AP transport in t