Improvement of the surface biocompatibility of silicone intraocular lens by the plasma-induced tethering of phospholipid moieties
✍ Scribed by Ke Yao; Xiao-Dan Huang; Xiao-Jun Huang; Zhi-Kang Xu
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 312 KB
- Volume
- 78A
- Category
- Article
- ISSN
- 1549-3296
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
To improve the surface biocompatibility of the silicone intraocular lens (IOL), 2‐methacryloyloxyethyl phosphorylcholine (MPC) was tethered onto the IOL through air plasma treatment. Chemical changes on the IOL surface were characterized by X‐ray photoelectron spectroscopy (XPS) to confirm the covalent binding of MPC. Morphologies of the IOL surfaces were observed by scanning electron microscopy (SEM) to optimize the plasma treatment process. The hydrophilicity and biocompatibility of the control and modified IOLs were compared by the measurements of water contact angle, platelet adhesion, macrophage cell culture, and lens epithelial cell (LEC) attachment. It was found that, after the tethering of MPC, the hydrophilicity of the IOL can be improved significantly and permanently, and the platelet, macrophage, and LEC adhesion on the IOL surface are obviously suppressed, which indicated the enhancement of surface biocompatibility. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006