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Improvement of surface bioactivity of poly(lactic acid) biopolymer by sandblasting with hydroxyapatite bioceramic

✍ Scribed by Ji-Young Bae; Jong-Eun Won; Jong-Sub Park; Hae-Hyoung Lee; Hae-Won Kim

Book ID: 113794710
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 787 KB
Volume: 65
Category: Article
ISSN: 0167-577X
DOI: 10.1016/j.matlet.2011.06.023

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## Abstract This work describes a simple method to immobilize heparin by covalent bonding to the surface of poly(lactic acid) film with the aim of showing improved hemocompatibility. Carboxyl groups present in heparin molecules were activated by reaction with __N__‐hydroxy‐succinimide and allowed t