Improvement of signal intensities in static secondary-ion mass spectrometry using halide additives and substrate modification
✍ Scribed by Gusev, Arkady I.; Choi, Bernard K.; Hercules, David M.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 237 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1076-5174
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✦ Synopsis
A new approach is reported for secondary-ion time-of-Ñight mass spectrometry (TOF-SIMS) sample preparation. The method involves the use of halide additives or halide modiÐcation of silver substrate surfaces to promote analyte cationization and protonation. The enhancement of signal intensity has been demonstrated for neutral organic lipophilic and hydrophilic compounds including various small peptides and nucleosides. Improvement factors range from 2-30 for cationized species to 20-2000 for protonated species. However, the new sample preparation does not a †ect the signal intensities of preformed ionic species. The sample preparation approach is applicable to a wide variety of neutral compounds and should Ðnd broad use for organic analysis by TOF-SIMS. 1998 ( John Wiley & Sons, Ltd.