Intestinal absorption and analgesic acti
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Takashi Mizuma; Kunihiro Ohta; Shoji Awazu
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Article
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1998
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John Wiley and Sons
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English
β 136 KB
Leucine enkephalinamide (LEamide), aminopeptidase-degradable opioid peptide, was coupled with cellobiose (cellobiose-coupled LEamide, CcpLEamide). CcpLEamide was absorbed from the rat small intestine in vitro, whereas LEamide was not. CcpLEamide on the mucosal side was more stable than aminopeptidas