Improvement of Erythromycin a purity and production at the fermentation stage of Saccharopolyspora erytharea by metabolic engineering

Improved E. coli erythromycin a producti

Improved E. coli erythromycin a production through the application of metabolic and bioprocess engineering

✍ Haoran Zhang; Karin Skalina; Ming Jiang; Blaine A. Pfeifer 📂 Article 📅 2011 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 926 KB

## Abstract In this report, small‐scale culture and bioreactor experiments were used to compare and improve the heterologous production of the antibiotic erythromycin A across a series of engineered prototype __Escherichia coli__ strains. The original strain, termed BAP1(pBPJW130, pBPJW144, pHZT1,