Improvement of Differentiation and Mineralization of Pre-Osteoblasts on Composite Nanofibers of Poly(lactic acid) and Nanosized Bovine Bone Powder

✍ Scribed by Eun Kyoung Ko; Sung In Jeong; Ji Hye Lee; Heungsoo Shin

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 763 KB
• Volume: 8
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200800089

✦ Synopsis

Abstract

The effect of NBM incorporation in PLA nanofibers on their mechanical properties and the differentiation and mineralization of osteoblasts was studied. At 20% NBM, the Young's modulus of the nanofibers was 37.78 ± 4.23, significantly larger than that of pure PLA nanofibers. MC3T3‐E1 pre‐osteoblasts attached to both types of nanofibers and developed full osteogenic phenotypes. A profound effect of NBM on the mineralization of MC3T3‐E1 pre‐osteoblasts was confirmed, suggesting that NBM/PLA composite nanofibers exhibit properties similar to those of the native collagen‐rich mineralized bone matrix, and could therefore serve as a temporary substrate for facilitating the differentiation and mineralization of bone‐forming cells.

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