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Improvement in the heterogeneous N-termini and the defective N-glycosylation of human interleukin-6 by genetic engineering

โœ Scribed by Masakazu HASEGAWA; Tetsuro ORITA; Tetsuo KOJIMA; Kikuo TOMONOH; Yuichi HIRATA; Norimichi OCHI


Book ID
115129676
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
431 KB
Volume
210
Category
Article
ISSN
1432-1327

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## Abstract Human genetic diseases that affect Nโ€glycosylation result from the defective synthesis of the Nโ€linked sugar moiety (glycan) of glycoproteins. The role of glycans for proper protein folding and biological functions is illustrated in the variety and severity of clinical manifestations sh