Improved yields of meta-amination and symmetrical and unsymmetrical diamination of benzenes

✍ Scribed by George R Brown; Alan J Foubister; Craig A Roberts; Stuart L Wells; Robin Wood

• Book ID: 104230648
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 81 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00582-2

✦ Synopsis

Much higher yields were found after shorter reaction times for the meta-substituted amination of benzenes in DMPU with microwave heating in a sealed tube (180°C, 5 h), e.g. piperidine and m-fluorobenzonitrile 1 gave the m-substituted 3 in 92% yield. These modified reaction conditions also afforded a new synthesis of unsymmetrical diamines in >80% yield.