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Improved visualization of breast lesions with gadolinium-enhanced magnetization transfer MR imaging

✍ Scribed by Wolfgang G. Schreiber; Gunnar Brix; Michael V. Knopp; Thomas Heß; Walter J. Lorenz

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
885 KB
Volume
35
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A pulse sequence with magnetization transfer as the main contrast mechanism (MT‐FLASH) was developed for improved imaging of breast lesions that requires neither fat suppression nor postprocessing. After optimization of the sequence in phantom and volunteer studies, a clinical pilot study with 14 patients was performed. In carcinomas the relative signal increase after Gd‐DTPA administration was on average 34% in MT‐FLASH images compared with 169% in conventional T~1~ weighted (T1W) three‐dimensional FLASH images. In MT‐FLASH images, all lesions demonstrated a signal intensity higher than that of fat; in T1W images, all lesions have a lower signal intensity. The average postcontrast carcinoma‐to‐fat contrast‐to‐noise ratios were +11.6 and −14.2, respectively. The conspicutty of 12 of 13 carcinomas was improved in postcontrast MT‐FLASH images compared with postcontrast T1w images. Thus, MT‐FLASH imaging enables excellent visualization of Gd‐DTPA‐enhancing breast lesions.

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