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Improved synthesis of V-PYRRO/NO, a liver-selective nitric oxide prodrug, and analogues

โœ Scribed by Sam Y. Hong; Joseph E. Saavedra; Larry K. Keefer; Harinath Chakrapani

Book ID
104096314
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
773 KB
Volume
50
Category
Article
ISSN
0040-4039

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An improved synthesis of V-PROLI/NO, a c
An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide prodrug
โœ Sam Y. Hong; Rahul S. Nandurdikar; Larry K. Keefer; Joseph E. Saavedra; Harinath ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 541 KB

An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide (NO) prodrug, in an overall yield of 26% in four steps from prolinol is reported; the previously published yield of this transformation was 1%. Using this revised strategy, the sarcosine analogue ( 14) of V-PROLI/NO was pr