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Improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for γ-secretase inhibitors

✍ Scribed by Fabienne Hoffmann-Emery; Roland Jakob-Roetne; Alexander Flohr; Fritz Bliss; Reinhard Reents

Book ID
104096898
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
232 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

An improved synthesis of (S)-7-amino-5H, 7H-dibenzo[b,d]azepin-6-one (1), involving a selective crystallization of epimeric menthylcarbamates for the resolution step followed by simultaneous cleavage of the carbamate and the lactam protecting group is described. Epimerization conditions of the undesired epimer have also been determined.

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