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Improved Synthesis of Phytosphingosine and Dihydrosphingosine from 3,4,6-Tri-O-benzyl-D-galactal

✍ Scribed by Youhong Niu; Xiaoping Cao; Xin-Shan Ye

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
185 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

An efficient and facile synthesis of phytosphingosine and dihydrosphingosine derivatives is described with less steps and in improved overall yield (66–72%) starting from commercially available tri‐O‐benzyl‐D‐galactal. The key steps include Wittig reaction, Mitsunobu transformation, reduction, and deprotection.

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