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Improved synthesis of dihydrothiophenes derivatives under ultrasound irradiation

✍ Scribed by Da-Qing Shi; Yi Zou; Yu Hu; Hui Wu

Publisher: Journal of Heterocyclic Chemistry
Year: 2011
Tongue: English
Weight: 137 KB
Volume: 48
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.662

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✦ Synopsis

Abstract

A series of dihydrothiphenes derivatives were synthesized via the four‐component reaction of aldehyde, malononitrile, 1,3‐thiazolidinedione, and piperidine at room temperature under ultrasound irradiation. Compared with the conventional methods, the remarkable advantages of this method are operational simplicity, higher yield, and shorter reaction time. J. Heterocyclic Chem., (2011).

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