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Improved Synthesis of Amino Acid and Dipeptide Chloromethyl Esters Using Bromochloromethane.

✍ Scribed by Paula Gomes; Maria Isabel Santos; Maria Joaquina Trigo; Raquel Castanheiro; Rui Moreira


Book ID
101949788
Publisher
John Wiley and Sons
Year
2003
Weight
99 KB
Volume
34
Category
Article
ISSN
0931-7597

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Selective N-monoalkylation of a-amino esters with activated alkyl bromides was studied using various alkali or alkali earth metal bases. In the production of N-monoalkylated amino ester derivatives and suppression of N,N-dialkylation, lithium hydroxide was more effective than any other alkali or alk