Improved synthesis of 5-hydroxylysine (Hyl) derivatives*
β Scribed by Cudic, M. ;Lauer-Fields, J.L. ;Fields, G. B.
- Book ID
- 110893836
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 311 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1397-002X
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π SIMILAR VOLUMES
The amino acid hydroxylysine was subjected to oxidation by sodium metaperiodate under various conditions. It was found that in acid and high temperature, the initial oxidation product o-aminoglutaric -r-semialdehyde was converted to glutamic acid with a yield of 60%. The use of alkaline conditions o
Different protective groups for (5R)-5-hydroxy-l-lysine were investigated in silver silicate promoted glycosylations with acetobromogalactose as glycosyl donor. Best results were obtained with Fmoc-Hyl(Cbz)-OAll, which was glycosylated in 80% yield. Removal of the allyl group gave a b-d-galactosylat