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Improved synthesis of 2-substituted 4-chlorothiazole-5-carbaldehydes

โœ Scribed by Norbert Debski; Wolfgang Hanefeld; Martin Schlitzer

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
160 KB
Volume
34
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

Abstract

An improved method for the reaction of 2,4โ€dichlorothiazoleโ€5โ€carbaldehyde (2) with secondary amines was established using potassium carbonate in acetonitrile at room temperature instead of deprotonation with butyllithium in tetrahydrofuran at โˆ’78ยฐ. The method is convenient and the yields of 3 even higher. Compound 2 could also be reacted by this method with thiophenols to yield 4โ€chloroโ€2โ€phenylthiothiazoleโ€5โ€carbaldehydes 4.

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