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Improved Synthesis and Spectral Characterization of D5281, an Oxadiazine Miticide/Insecticide

โœ Scribed by Dekeyser, Mark A.; Mitchell, D. Scott; Downer, Roger G. H.


Book ID
121267339
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
253 KB
Volume
42
Category
Article
ISSN
0021-8561

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On treatment with 10% HF, butenolides 4a and 4b afforded enantiopure (-)-syringolides 1 (la) and 2 (lb) respectively in much higher yields. Unprecedentedly, the cyclic acetal 5a was also converted to la by reacting with an excess of p-TsOH. The structure of the ~ynthetic (-)-syringolide 1 (la) was s