Chiral synthesis and pharmacological eva
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Maria Novella Romanelli; Alessandro Bartolini; Carlo Bertucci; Silvia Dei; Carla
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Article
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1996
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John Wiley and Sons
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English
โ 527 KB
The enantiomers of 3-a-tropyl 2-(phenylthio) butyrate (SMT2, 1 ) were prepared by chiral synthesis and tested for analgesic, cognition-enhancing, and ACh-releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R-( +)-hyoscyamine.