Improved survival following injection sclerotherapy for esophageal varices: Final analysis of a controlled trial

✍ Scribed by David Westaby; Brian R. D. Macdougall; Roger Williams

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 363 KB
• Volume: 5
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840050520

✦ Synopsis

Long-term follow-up (median: 37 months; range: 19 to 68) of the 116 patients (66 sclerotherapy, 60 control group) entered into a controlled trial of endoscopic variceal sclerotherapy has shown a total of 18 deaths in the sclerotherapy group, including five from variceal bleeding compared with 32 deaths in the control group (p < 0.01), of which 26 were from variceal hemorrhage (p < 0.001). Survival as 8888888d by cumulative life analysis was significantly better in those treated by sclerotherapy (p < 0.001). Both the cumulative proportion of patients rebleeding and the total number of episodes of variceal hemorrhage were also significantly less in the sclerotherapy group (p < 0.01). Recurrence of varices was observed in 27 of 46 patients in whom variceal obliteration was initially observed at a median of 11 months (range: 2 to 27) later, although in only 12 of these did bleeding recur and was the cause of death in one.