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Improved Sequence Resolution by Global Analysis of Overlapped Peptides in Hydrogen/Deuterium Exchange Mass Spectrometry

✍ Scribed by Piotr G. Fajer, George M. Bou-Assaf, Alan G. Marshall

Book ID: 113110740
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 347 KB
Volume: 23
Category: Article
ISSN: 1044-0305
DOI: 10.1007/s13361-012-0373-3

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## Abstract Gramicidin A (the major component of gramicidin D) is a highly hydrophobic peptide with very little solubility in water. Hence, the conformation of this peptide has been extensively investigated in organic solvents and model membranes, but not in water. The peptide adopts a β^6.3^‐helic