Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment
✍ Scribed by Jürgen Hennig; Thorsten Thiel; Oliver Speck
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 515 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A method for volume selective proton spectroscopy is presented based on a multiecho sequence with short refocusing interval tcp. It is demonstrated, that by appropriate choice of tcp on the order of 4–6 ms, signals from overlapping multiplets like the glutamine and glutamate (Glu/Gln) resonances in spectra of the human brain are considerably increased compared with a conventional PRESS volume selection scheme. Thus proton spectra from J‐coupled multiplet signals can be acquired with TE on the order of 20–30 ms avoiding the baseline problems arising at shorter echo times due to broad resonances. This allows to selectively acquire spectra from substances with longer T~2~ without the confounding effects from J‐coupling occurring in conventional volume selection techniques.