Improved routes to methyl 4-methylimidazole-2-carboxylate and methyl 5-methyl-1,2,4-triazole-3-carboxylate
β Scribed by Oliver, James E.; Sonnet, Philip E.
- Book ID
- 121358840
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 257 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Single-crystal X-ray study T = 294 K Mean (C-C) = 0.005 A R factor = 0.052 wR factor = 0.148 Data-to-parameter ratio = 12.7 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
The title compound, C 14 H 16 N 2 O 4 S, was synthesized by the reaction of 4-hydroxy-3-methoxybenzaldehyde, thiourea and methyl 3-oxobutanoate in ethanol under reflux. The crystal structure is stabilized mainly through intermolecular N-HΓ Γ ΓS and O-HΓ Γ ΓO hydrogen bonds. The tetrahydropyrimidin-2
Shikimic acid (~-1) was first isolated from the oriental plant Illicium religiosum (in Japanese, shikimi) in 1885 by Eijkma&. After nearly 50 years, thanks to the pioneering works of Fischer and Dangschat4 during the 1930's, the complete structure and absolute stereochemistry of this acid were estab