𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Improved protocol towards isotopically labelled 1-deoxy-D-xylulose

✍ Scribed by Andreas Jux; Wilhelm Boland

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
123 KB
Volume
40
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The key-operation is a novel one-pot reductive alkylation of the protected halfester 3, by sequential treatment with superdeuteride(hydride) and methyl lithium, providing the protected I-deoxy-D-xylulose (5) in high yield.

📜 SIMILAR VOLUMES

Highly Efficient and Versatile Synthesis
Highly Efficient and Versatile Synthesis of Isotopically Labelled 1-Deoxy-D-xylulose
✍ Jörn Piel; Wilhelm Boland 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 606 KB

An efficient and versatilesynthesisof ldeoxy-[4,4-2H2] -L2-xyhdose lb (= ldeoxy-[4,4-2H2] -othreopentuloae) fromdimethyl2,3-O-isopropyli&ne-mtartrate in 31Y.overallyield is deaeribed. The synthetic protocolallows a flexible adaptationto otherIabellingpatternsand isotopes.Labelledldeoxy-xyhrkraeis of

An Improved Preparation of D-Glyceraldeh
An Improved Preparation of D-Glyceraldehyde 3-Phosphate and Its Use in the Synthesis of 1-Deoxy-D-xylulose 5-Phosphate
✍ Heng Li; Jie Tian; Hui Wang; Shao-Qing Yang; Wen-Yun Gao 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 German ⚖ 157 KB 👁 1 views

## Abstract D‐Glyceraldehyde 3‐phosphate (=D‐GAP; **2**) was prepared by an improved chemical method (__Scheme 2__), and it was then employed to synthesize 1‐deoxy‐D‐xylulose 5‐phosphate (=DXP; **3**) which is enzymatically one of the key intermediates in the MEP (**4**) terpenoid biosynthetic path