Highly enantioselective reduction of 3,4-dihydro-2,2-dimethyl-2H-l-benzopyran-4-ones 3 s-e by BH3 was achieved in the presence of catalytic amounts of Corey's oxazaborolidine 4 to afford the corresponding 3,4-dihydro-2,2dimetbyl-2H-l-~nzopyran-4-ols 2a-e in quantitative yields. These benzopyran-4-ol
Improved procedure for the preparation of 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ones
โ Scribed by F. Camps; O. Colomina; A. Conchillo; A. Messeguer
- Book ID
- 112128019
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1985
- Tongue
- English
- Weight
- 235 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-152X
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๐ SIMILAR VOLUMES
The chiral intermediate diol (3S,4R)-trans-3,4-dihydro-3,4-dihydroxy-2,2dimethyl-2H-1-benzopyran-6-carbonitrile 2. was prepared for the total synthesis of a potassium channel opener drug candidate. The stereoselective acetylation of racemic lwas carded out with various lipases among which the lipase
we describe a convenient and general method for the preparation of 2,3-dihydro-2-niuo-3-phenyl-4H-furo[3,2-c][l]~~opy~-4-ones from cl-hydroxycoumarin and (2-chloro-2-nitroethenyl)benzenes in the presence of potassium fluoride. Using the same starting materials and by replacing potassium fluoride wit