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Improved procedure for 3,4-dihydro-1H-2-benzopyran ring closure. A general access to 3-substituted isochromanes

✍ Scribed by Roberto Antonioletti; Paolo Bovicelli; Benedetta Crescenzi; Paolo Lupattelli

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
102 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A general method for the ring closure of I-substituted 2-(-hydroxymethyl)phenylethanols to 3-substituted isochromanes using p-TsOH supported on silica gel is reported.

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✍ Daniel Dauzonne; Hubert Josien; Pierre Demerseman πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 French βš– 640 KB

we describe a convenient and general method for the preparation of 2,3-dihydro-2-niuo-3-phenyl-4H-furo[3,2-c][l]~~opy~-4-ones from cl-hydroxycoumarin and (2-chloro-2-nitroethenyl)benzenes in the presence of potassium fluoride. Using the same starting materials and by replacing potassium fluoride wit