✦ LIBER ✦

Improved pharmacokinetics of AMG 517 through co-crystallization part 2: Analysis of 12 carboxylic acid co-crystals

✍ Scribed by Mary K. Stanton; Ron C. Kelly; Adria Colletti; Meghan Langley; Eric J. Munson; Matthew L. Peterson; John Roberts; Mary Wells

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 474 KB
Volume: 100
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.22502

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Improved pharmacokinetics of AMG 517 thr

Improved pharmacokinetics of AMG 517 through co-crystallization part 1: Comparison of two acids with corresponding amide co-crystals

✍ Mary K. Stanton; Ron C. Kelly; Adria Colletti; Y.-H. Kiang; Meghan Langley; Eric 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 326 KB

The dissolution and pharmacokinetics (PK) of two carboxylic acid co-crystals (cinnamic acid and benzoic acid) with the corresponding amide co-crystals (cinnamamide and benzamide) of AMG 517 were investigated. Powder and intrinsic dissolution studies were performed in fasted simulated intestinal flui

The co-crystal approach to improve the e

The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics

✍ Annette Bak; Anu Gore; Evelyn Yanez; Mary Stanton; Sunita Tufekcic; Rashid Syed; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 591 KB

Co-crystals are relatively novel in the pharmaceutical field and are not reported extensively. AMG 517 is an insoluble small molecule VR1 (vanilloid receptor 1) antagonist. In animal studies, good exposure of AMG 517 is seen from a 10% (w/v) Pluronic 1 F108 in OraPlus 1 suspension. Investigation of