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Improved pharmacokinetics and stability properties of catalase by chemical glycosidation with end-group activated dextran

✍ Scribed by Reynaldo Villalonga; Aymara Valdivia; Yunel Pérez; Bertha Chongo

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 70 KB
Volume: 102
Category: Article
ISSN: 0021-8995
DOI: 10.1002/app.25019

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✦ Synopsis

Abstract

Catalase was chemically modified with a monoactivated dextran derivative having a carboxylate group at its reducing end residue. The modified enzyme retained 77% of its initial specific activity and was 3‐fold more resistant to tryptic degradation. The plasma half‐life time was increased to 7.3‐fold after glycosidation. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 4573–4576, 2006

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