Improved myo-inositol detection through Carr–Purcell PRESS: A tool for more sensitive mild cognitive impairment diagnosis
✍ Scribed by Ileana Hancu; Robert Gillen; John Cowan; Earl A. Zimmerman
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 638 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A 3‐T study is presented, comparing the ability of two ^1^H spectroscopy pulse sequences, Carr–Purcell point resolved spectroscopy (CPRESS; TE = 45 msec), and conventional PRESS (TE = 35 msec), to separate between groups of 20 normal control (NC) and 20 mild cognitive impairment (MCI) subjects. Both sequences showed higher myo‐inositol (mI) and mI/N‐acetyl‐aspartate (NAA) levels in the posterior cingulate gyrus of the MCI subjects. The increased intrasubject repeatability of mI and mI/NAA CPRESS measurements (∼6% vs. 9% for PRESS) translated into decreased intraclass variability. A 22% intraclass mI PRESS variability was reduced to 16% for CPRESS, and an 18% intraclass mI/NAA PRESS variability was reduced to 12% for CPRESS for the group of NC subjects. Similar results were observed for the MCI subjects. Decreased intraclass variability led to improved separation between NC and MCI subjects (P = 0.017 for PRESS and P < 0.0001 for CPRESS mI/NAA, the best NC/MCI discriminant for each method). Seventy‐five percent sensitivity at eighty percent specificity was demonstrated by mI/NAA CPRESS measurements in separating NC from MCI subjects. High correlations were also observed between subject performance on a number of neuropsychological tests (probing verbal memory, visuoconstruction performance, and visual motor integration) and the mI/NAA ratio; higher correlation coefficients (with stronger statistical significance) were consistently evident for CPRESS than for PRESS data. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.